Revista Pan-Amazônica de Saúde
versão On-line ISSN 2176-6223
STORTI-MELO, Luciane Moreno et al. The frequency of HLA-DRB1 polymorphisms in Brazilian Plasmodium vivax malaria patients and in blood donors from the Amazon Region. Rev Pan-Amaz Saude [online]. 2010, vol.1, n.4, pp. 51-55. ISSN 2176-6223. http://dx.doi.org/10.5123/S2176-62232010000400008.
We evaluated the frequency of different HLA-DRB1 alleles in Plasmodium vivax-infected individuals and in healthy blood donors from malaria endemic areas of Brazil. Low-resolution human leukocyte antigen-DRB1 genotyping was performed for 73 malaria patients and 29 healthy blood donors. The most frequent alleles in individuals from northern Brazil were human leukocyte antigen-DRB1*04, *08, *07 and *13. The frequency of human leukocyte antigen-DRB1*07 was higher in malaria-infected individuals than in the control group, which reinforces the theory that this allele plays an important role in susceptibility to malaria. This study offers new information about a potential susceptibility factor for P. vivax malaria in a Brazilian population that is naturally exposed to malaria.
Palavras-chave : Malaria; Plasmodium vivax; MHC Class II genes.